The calciferol receptor (VDR) is a health proteins that is turned on by vitamin D. It is involved with maintaining the mineral stability in the body and leading to growth and hair creation. It also interacts with adipose muscle.
VDRs are expressed inside the parathyroid glands, intestines, epithelial cellular material, and many immune system cell types. They are thought to regulate the intestinal consumption of calcium mineral, and to mediate some of the associated with vitamin D in bone routine service. Also, they are thought to perform an important role in metabolic rate.
VDR is found in a variety of tissues, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they are really most widely stated in the kidneys and osseous matter.
The VDR is phosphorylated upon serine elements by a variety of protein kinases. These kinases include PKA and PKC. The effect for these kinases on VDR is certainly ligand based. Specifically, the phosphorylation of Ser51 by PKC decreased VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.
Studies have shown that VDRs can be found in a subset of glial cells, specifically https://dataroomsearch.net/vdr-is-to-access-your-companys-valuable-assets-from-anywhere-on-the-web/ in oligodendrocytes in white matter. Although VDR immunoreactivity has been diagnosed in a number of glial cell lines, no data has been presented that the occurrence of VDR in glia is a cause for increased likelihood of tumorigenesis.
In addition , VDR seems to be present in a subset of neurons. In fact , nuclear discoloration has been demonstrated in man cortex and glial cell-lines.
A large 220-kDa protein is found in human primary glioblastoma cells. In contrast, a little recombinant VDR-like protein was produced.
